Probenecid, nephrotic syndrome, and renal failure.

Probenecid, nephrotic syndrome, and renal failure.

Case 1, an electrical engineer, had had recurrent gouty arthritis since the age of 14 years. A paternal uncle had also suffered with gout. From the age of 50 onwards numerous tophi appeared on the hands, feet, elbows, and ears. At one time or another he had been given various drugs, including corticosteroid hormones, phenylbutazone, salicylates, and probenecid. These drugs had produced no harmf...

Acute renal failure in the nephrotic syndrome.

Sir, In their article in Nephrology Dialysis Transplantation w1x, discussing the pathophysiology of acute renal failure in the nephrotic syndrome, Koomans et al. (p. 223) mention that obliteration of epithelial slit pores, as visualized by electron microscopy, is not correlated with the reduction in glomer-ular ®ltration rate (GFR) in humans. However, in a previous

Nephrotic Syndrome and Acute Renal Failure Apparently Induced by Sunitinib

We report a case of nephrotic syndrome and acute renal failure apparently induced by sunitinib. A 67-year-old man with a history of metastatic renal cell carcinoma presented with progressive kidney dysfunction with proteinuria, general edema, and body weight gain of 21 kg after undergoing 3 weeks of sunitinib therapy. The patient had taken no other over-the-counter medications, and all other po...

Pathophysiology of acute renal failure in idiopatic nephrotic syndrome.

Chronic Renal Failure, Focal Segmental Glomerulosclerosis, Nephrotic Syndrome

The collapsing variant of focal segmental glomerulosclerosis (FSGS) is a renal injury that may be idiopathic or associated with various factors; it is characterized by glomerular collapse, which leads to steroid-resistant nephrotic syndrome (NS) and progressive chronic renal failure. FSGS has not been well studied in children, in which most of the cases are idiopathic. We report six cases of th...